Biochemistry; protein structure and function relationships; protein dynamics; chemotaxis in bacteria.

The role of radicals in enzyme catalysis and degradation, development of electron bifurcating flavoproteins, and biogeochemical redox cycling of phosphorus.

Combining theory and experimentation to understand how navigational decisions come about in terms of neural-circuit computation.

Microbial pathogenesis; innate and adaptive immune responses to infection; coagulopathy and inflammation of sepsis; vaccine development.

Bio-nano technology including molecular mechanisms controlling self assembly, emergent properties of biomolecular systems from minerals to dynamically tunable color in octopus skin; translation to revolutionary new routes to semiconductors, optoelectronics and energy.

  Enzymology of enzymes that modify nucleic acids, including bacterial and human epigenetic enzymes with biomedical relevance. Protein engineering, inhibitor design. Drug development. Nanoparticle-based delivery of siRNA, proteins, and drugs into cells (cancer/embryonic stem cell) and animals. Laser-dependent spatio-temporal control of drug targeting.
    

Quantitative systems biology and bioinformatics; statistical mechanics of non-equilibrium systems.

Ion channels in the nervous system and cardiac muscle; molecular mechanisms of ion channel trafficking, regulation, and signal transduction.

The Weimbs Lab is centered around two related areas of investigation:  Autosomal-dominant polycystic kidney disease and SNAREs and epithelial cell polarity.